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Acne Medication Potential Side Effects

Patients with mild or occasional acne may be able to treat themselves without the use of prescription medication. Such remedies may include an alteration in diet and exercise habits, regular cleansing to remove residue and buildup on the skin, choosing the right cosmetics and eliminating stress. But for some individuals, this simply isn’t enough. For those who suffer from moderate to severe acne, a stronger medication may be needed in order for that individual to find relief from their condition.

There are several different types of medication that are commonly used to treat acne, each of which may contain the potential for certain side effects. As is the case with most over-the-counter acne medication, prescription medicines are usually available as gels, creams, lotions or solutions. In determining which is the best choice for the patient, a physician will study the skin type, severity of acne and the patient’s likelihood of having a negative reaction to any medication. Once a prescription is written, the physician will explain how often to use the medicine and how to properly apply it to the skin.

As mentioned previously, it is not uncommon for individuals to have a reaction to strong acne medication. For some it is only temporary, but others may require a change in their prescription. The most widely seen reaction is that of the skin’s condition actually worsening. Many physicians agree that most medications will cause the skin to worsen before it actually improves, which may take 6-8 weeks of using a medication. However, additional side effects may include extreme redness, burning, stinging, peeling, soreness, scaling or a discoloration of the skin. If individuals notice these side effects becoming increasingly worse or if they do not go away after a specified period of use, which should be indicated by a physician, the medication may need to be changed.

Individuals who take oral medications for the treatment of acne may face an entirely different set of potential side effects, including an upset stomach, dizziness and skin discoloration. Certain types of medication can be dangerous to women who are pregnant or children under a certain age, so individuals should report any possible conditions to their physician prior to accepting a prescription.

As with any medication, there are often risks and benefits of it’s use. The best way to learn of these is to speak with a physician, ask about any potential side effects and completely disclose your current medical condition and any medications that you are currently taking. In some instances, medications may negatively react with one another and this can be very dangerous to the patient. Acne medicine is no different and the patient should have a complete understanding of how it operates before using it.

The information in this article is intended for informational purposes only. It should not be considered as, or used in place of, medical advice or professional recommendations for the cause, diagnosis or treatment of acne. If necessary, individuals should consult a medical doctor or dermatologist for information regarding the use of acne medication or other effective treatment methods.
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Holiday Shopping: Friends and Family Discount at Macy's

Holidays are getting closer! Are you shopping for presents? I bet you are! And it is even more fun when you can shop for holiday presents at a sale! So, make sure not to miss Macy’s great Friends and Family sale. I learnt about this coupon you can use to get a 20% discount from Wednesday, December 10 till Monday, December 15.Download the Macy's Friends and Family Coupon in pdf format.Happy
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The Manganese and Hyperactivity Connection

In a previous post, we examined whether lead exposure was responsible for worsening ADHD symptoms. We saw that there is a solid (although still somewhat hypothetical) connection between lead and hyperactive behavior. This lead to the blog's conclusion that high lead levels (the exact amount is still hotly debated, but a federal recommendations appear to be headed to a cutoff of around 10 micrograms lead/deciliter of blood. This converts roughly to half of a gram of lead total in the entire blood supply in the average adult male, or less than half a gram of lead total in a child's blood). This post can be found here.



A follow-up post suggested that adequate iron intake can help counteract some of lead's negative effects on ADHD and related symptoms through a variety of possible mechanisms. A link to this blog post can be found here.



Now it appears that another metal may be connected to hyperactivity. While the connection between manganese and hyperactivity appears to be more strained that that between lead and hyperactivity, it is at least worth mentioning. Additionally, manganese seems to be less tied to actual ADHD behavior (including inattention and impulse control problems alongside hyperactivity), and more towards generalized hyperactivity. Nevertheless, like the post on lead and hyperactivity mentioned previously, there at least remains that possibility that unhealthy buildup of manganese in the body may lead to hyperactive behavior. This could, at least hypothetically, "push" an individual with the predominantly inattentive form of ADHD to more of a mixed or combined subtype of ADHD, which includes hyperactive/impulsive behavior as well. A study of French Canadian children who lived in an area with naturally high levels of manganese found a significant tie-in between high manganese levels and hyperactive behavior. A summary of that study can be found here. Some key points of the article (along with some of my thoughts and comments) are listed below:
  • Hair samples, while not a perfect method of evaluating manganese intake, is typically a good indicator of overall manganese exposure. This was the method used in the study of children in a region of Quebec, Canada with naturally high manganese levels in the drinking water. Children whose drinking water source came from a well with higher manganese levels showed consistently higher manganese levels in their hair samples.

  • 46 children, ages 6-15 were examined in the study. Most were previously non-medicated and untreated for ADHD or related conditions before the study.

  • A strong positive correlation was seen between high manganese levels in the hair and oppositional behavior scores in the children, as based on the teacher rating scale mentioned above. This was done using a form of the revised Connner's Teacher rating scales (a common method used for diagnosing ADD, ADHD and related symptoms and behaviors). For a brief synopsis of the different elements or categories of Conner's rating scales, please click here. Briefly, oppositional is characterized by "angry" or "annoyed" temperament as well as "rule-breaking" behavior.

  • Additionally, an even stronger statistical correlation was seen between high manganese hair levels (above the study threshold level of 3 millionths of a gram of manganese per gram of hair sample, which was established based on detection methods and previous studies) and hyperactivity. Here, hyperactivity is characterized by restlessness and the inability to sit still, impulsive behavior and the inability to maintain adequate focus for a given task.

  • Every single child who displayed the necessary score to be considered "hyperactive" or "oppositional" had manganese levels above the study cutoff amount of 3 millionths of a gram of manganese per gram of hair. Additionally, a large majority (11 of 13), who tested above the critical score for ADHD risk had manganese levels above the cutoff mark mentioned above.

  • In contrast, cognitive problems (i.e. difficulty concentrating, slow learning, poor organizational skills) did not seem to be linked to manganese levels based on the study. Hypothetically, this suggests that high manganese exposure, should it be a factor in the onset and symptomology of ADHD, would likely be aligned or affiliated more with the hyperactive/impulsive subtype of ADHD and less towards the inattentive form of ADHD.

  • Interestingly, the high degree of connection between high manganese levels and hyperactivity or oppositional behavior was not present in an analogous Conners Parent rating scale as it was for the teacher rating scale. While it may be simply due to differences in observational patterns and previous history with the children (i.e. parents may be more "accustomed" to specific behaviors based on long-terms relationships, or may be less objective in identifying problem behaviors in their children for a study), this should raise some questions to the replicability of this study and its findings. Additionally, it is possible that some of these observed behaviors are more relevant to an academic setting, and solutions such as trying to reduce manganese exposure at home, may provide more benefits in the classroom than at home. None of these should be ruled out as possibilities.

  • ***Blogger's note: The following 2 points was addressed briefly in the manganese article, are rather long and complex and stray slightly off-topic. They can be omitted if necessary. Nonetheless, I think there are some interesting affiliations between this post, which deals primarily with manganese and common symptoms seen in ADHD and related disorders, and previous posts, which have dealt with genes associated with ADHD.
  • Signaling and proper communication in the nervous system is dependent on certain chemicals such as GABA (which is also important for proper muscle tone and function) as well as dopamine and their respective systems or "targets". These complex systems in the body have been shown to be effected by high manganese levels. The negative effects of high manganese exposure are thought to work through these very systems. A quick summary of a study done on this can be found here.
  • Interestingly, the very systems associated with these two agents (GABA and dopamine) are also thought to be affiliated with hyperactivity. A summary and link to the full article on this can be found here. Note that this study investigated a genetic connection between these systems and the onset of ADHD. Some of the genes indicated in this paper have been investigated in previous posts on this blog. Among these are the DRD4 gene, the DRD5 gene, and the DAT gene.

  • There appear to be slight but noticeable differences based on age and sex. Based on the teacher (but not parent) rating scales, older children appeared to have more severe symptoms of ADHD behavior, hyperactivity, cognitive impairment and oppositional behavior. While the effects were relatively small, there remains the possibility that cumulative exposure to elevated levels of manganese can lead to increased impairment over time. However, I am personally not comfortable in making this assertion based solely on the limited scope of this study.

  • What I did find interesting was the fact that girls showed substantially higher manganese concentrations in their hair samples than did boys. I am intrigued by the possibility that there may be hormonal reasons behind this, especially given the context of a previous post which mentioned that magnesium has a tendency to be stored better in females due to the effects of estrogen, and iron levels are thought to be lower in females due to menstruation as well as other effects.

While the study made several noteworthy observations, there are too many loose ends and questions left to be answered before determining whether manganese can pose similar risks to lead as far as inducing hyperactive behavior and ADHD-related symptoms. As of now, we are unsure whether the effects were do more to interference with iron absorption (given that numerous studies have shown that individuals with ADHD are typically iron deficient) or through a non-iron-based regulation of the GABA and dopamine pathways mentioned above. Further clouding this is the fact that iron itself plays a key role in dopamine synthesis and manufacturing.

As of now, my conclusion is that there is a possible correlation between high manganese and ADHD (especially the hyperactive form), but this connection is much weaker than that of lead (which is debatable in its own right at the moment). It certainly appears that manganese is more tolerable and overall more benign than lead, at least with regards to similar levels of exposure.

Unlike lead, manganese is actually a trace element micronutrient (i.e., it's good for the body at low levels). Manganese-rich foods include teas, beans, nuts and many types of whole grains. Additionally, excess manganese can be cleared more easily from the body than can lead. While common sources are food and drinking water (with water thought to be a more potent source of intake than food), inhalation is also a common mode of entry. This is especially true of specific occupations such as welders. Typical blood manganese levels hover around 1 microgram of manganese/deciliter of blood. This roughly translates into about .05 grams total manganese in the bloodstream.

It is easy and often tempting to try to assimilate anything and everything to a disorder such as ADHD. Many professionals and researchers often fall into this trap. However, I caution against this, since this clouds the picture as to what the real underlying causes of the disorder might be. That is why I urge restraint before passing judgment on this particular metal, at least in regards to its causative role with respect to ADHD and related disorders.

Certainly, manganese toxicity is a problem, with the deleterious effects of manganism (sometimes referred to as "manganese poisoning" and is characterized by loss of balance and coordination and impaired reaction timing) going back hundreds of years and still seen in certain metal-related occupations such as welding. Nevertheless, the relative ease of excretion of manganese (at least when compared to other heavy metals such as lead) and somewhat higher limits of tolerability make it a possible foe in the ADHD symptom world, but not a powerful one, at least for the time being.

In the next post, we will be shifting gears a bit and looking into the connection between celiac disease and ADHD and its degree of association with specific symptoms of the disorder.

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Beauty Buzz: Estee Lauder Holiday Collection 2008

Holiday Collection 2008 from Estee Lauder was inspired by vintage jewels: Amethyst, Sapphire and Emerald. There are three corresponding looks and beautiful makeup products to achieve them.Sapphire Eyes:Estée Lauder Signature Silky Eyeshadow Duo with Faceted Design in Sapphire Limited Edition)Smoked Eye Pencil in Smoked SapphireSapphire Lips and Nails:Estée Lauder Signature Hydra Lustre Lipstick
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Using Iron to Combat the Effects of Lead in ADHD

In the previous post, we were discussing the potential connection between lead exposure early in life and the subsequent onset of ADHD symptoms. We saw that higher lead levels are more likely to be associated with the hyperactive or impulsive symptoms of ADHD than the inattentive symptoms. At the moment, the amount of lead necessary to precipitate these negative symptoms is debatable, especially when individual variations are taken into account. However, a rough estimate of upper level lead limits can be found here. At the end of the post, I alluded to the fact that iron supplementation either via diet or pills may be effective as a possible treatment option. I will go into some of the details here:

Iron supplementation has been found to be useful in multiple cases regarding ADHD. Numerous studies have indicated that a large percentage of individuals with ADHD are iron deficient. Iron is responsible, among other things, for the synthesis and regulation of levels of the key brain chemical dopamine. Dopamine deficiencies are often seen in multiple brain regions (especially in the area behind the forehead, called the prefrontal cortex) in individuals with ADHD. Additionally, iron is a key component of hemoglobin, which is responsible for carrying oxygen in the blood to other organs and tissues in the body. Not surprisingly, many ADHD individuals have lower than average oxygen levels delivered to their brains.

Finally, other co-existing or comorbid disorders of ADHD also have been associated with iron deficiencies. One of the most notable is Restless Leg Syndrome (RLS), which is characterized by unwanted leg movements during rest, and is thought to be a major contributing factor to many types of sleep disorders and impairments. Individuals with ADHD have been shown to suffer from Restless Leg Syndrome at disproportionately high frequencies, when compared to the general population and iron deficiency may be a key contributing factor to Restless Leg Syndrome seen alongside ADHD.

However, one of the unexpected benefits of iron, especially with regards to ADHD, is its potentially protective role in reducing the negative effects of early lead exposure. In a couple of correspondences in the August 2007 edition of the journal Environmental Health Perspectives, some key findings were summarized involving the protective role of iron to lead-induced damage. One of them (based on previous literature) reported on how lead can negatively impact levels of free dopamine (which is often correlated with ADHD, as many of the positive effects derived from most stimulant medications is due to their abilities to boost levels of dopamine in between neuron cells).

Additionally, lead is also thought to inhibit the interactions of dopamine and its targets as lead can alter the presence of these targets or dopamine receptors. Both of these reduce proper dopamine function, and it is thought that adequate levels iron can offset some of these negative effects (on the flip side, iron deficiencies are thought to exacerbate several of these negative occurrences). Finally, iron is also thought to restore a balance in the blood-brain barrier, which serves as a sort of controlled gateway, regulating the passage of nutrients and necessary neuro-signaling chemicals into (as well as keeping toxic substances out of) the brain. The role of iron is thought to restore and offset some of the negative and damaging effects of lead on the blood-brain barrier, which is especially sensitive to toxins during the early stages of life and childhood.


There is some dispute and controversy over some of these findings, however. Another study (which is frequently cited in numerous journals on toxins/heavy metals and ADHD or cognitive disorders) was done on the protective effects of iron and zinc on Mexican schoolchildren exposed to lead showed no statistically significant results as far as improving cognitive function.

While I do not advocate excessive iron supplementation, (watch for upper limits which are described here), I do strongly suggest that pregnant and nursing mothers, as well as children and adults with ADHD do ensure that their iron intake is adequate. It is interesting to note that magnesium deficiency is also affiliated with increased ADHD symptoms. Due to the role of estrogen in improving magnesium retention, women require less daily magnesium than do men (a table of recommended daily magnesium intake can be found here). However, in iron, the opposite is true. Several factors, including less efficient iron binding and loss of iron due to menstruation and pregnancy result in higher iron requirements in pre-menopausal women. A summary of recommended iron levels for men women and children can be found here.

In addition to the potential role of iron in protecting against lead damage, will be discussing how boosting iron intake can offset the effects of ADHD and other related comorbid disorders in future posts.
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Beauty Talk: Sensitive Skin Care Ingredients

I decided to talk in more detail about some soothing, calming, anti-inflammatory ingredients that can be beneficial to sensitive skin. I have already mentioned in my previous post several of those listed below. But this time I had a closer look at them. I will be adding more ingredients to this list if I find the ones I consider important.Allantoin aids in formation of healthy tissue. Allantoin
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Beauty Buzz: Yves Saint Laurent Holiday Collection 2008

YSL holiday collection is in tune with their autumn-winter 08/09 tuxedo inspired look.YSL THE BOW COLLECTION 4 Colour Eye Shadow- palette of four eye shadows which reinvent the smoky eye in golden plum and rosy grey tones.YSL THE BOW COLLECTION Duo Lip Colour Palette- This bow accessory, inspired from the famous “Bow” bag was created to celebrate the 30th anniversary of YSL make up. Inside you
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